HCID 69320119, compound → HCID 86598328, compound

HRID 1393385Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:21])[C@H:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](O)[CH:15]=1)[NH:6][C:7](=[O:12])[C:8]([F:11])([F:10])[F:9])[CH3:2].[CH2:22]([O:29][CH2:30][CH2:31][N:32]([CH2:46][CH2:47][O:48][CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)[C:33]1[CH:42]=[CH:41][CH:40]=[C:39]2[C:34]=1[CH:35]=[CH:36][C:37](B(O)O)=[CH:38]2)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:21])[C@H:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:37]2[CH:36]=[CH:35][C:34]3[C:39](=[CH:40][CH:41]=[CH:42][C:33]=3[N:32]([CH2:46][CH2:47][O:48][CH2:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[CH2:31][CH2:30][O:29][CH2:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:38]=2)[CH:15]=1)[NH:6][C:7](=[O:12])[C:8]([F:11])([F:10])[F:9])[CH3:2]

Participants

Reactant 2

HCID 69320119HCID 69320119, compound

HCID 86598324HCID 86598324, compound

Product 1

HCID 86598328HCID 86598328, compound

Procedure

3-[5-Bis[2-(benzyloxy)ethyl]amino-naphth-2-yl]-N-trifluoroacetyl-L-phenylalanine ethyl ester was synthesized in a similar manner to Example 49 from N-trifluoroacetyl-3-hydroxy-L-phenylalanine ethyl ester and 5-bis[2-(benzyloxy)ethyl]amino-2-naphthaleneboronic acid.

Sources & evidence

ORD record: ord-eb0a57667ee8429790b29ac2da3ac371
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07345068B2

Reaction notes

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