HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Methyl-2-thiophen-2-yloxazol-4-yl)ethyl tosylate → (S)-2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-2-(4-trifluoromethyl-phenoxy)-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Methyl-2-thiophen-2-yloxazol-4-yl)ethyl tosylate | HCID 22340042 | — |
| Reactant | HCID 69318029 | HCID 69318029 | — |
| Product | (S)-2-Methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-2-(4-trifluoromethyl-phenoxy)-propionic Acid | HCID 60024287 | — |
Reaction Steps
The title compound was prepared from (S)-3-(4-hydroxyphenyl)-2-methyl-2-(4-trifluoromethyl-phenoxy)-propionic acid ethyl ester (95% ee; Chiralpak AD separation, 8×27 cm, 10% IPA/heptane, 275 nm) and toluene-4-sulfonic acid 2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethyl ester by the procedure described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345070B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-4488667a06404eb8baf2f511644708b0 |
| Source note | uspto-grants-2008_03 |