Hydrochloric Acid → 2-Hydroxyethyl Methacrylate

Participants

Reaction Steps

A screw mouth-type bottle containing 55.4 g (0.43 mol) of hydroxyethyl methacrylate (trade name: Acryester HO; manufactured by Mitsubishi Rayon Co., Ltd.) and 37.0 g (0.44 mol) of dihydropyran (trade name: 3,4-Dihydro-2H-pyran; manufactured by Wako Pure Chemical Industries, Ltd.) is tightly closed by a rubber plug (Biton plug) and immersed in an ice bath. 0.47 g of concentrated hydrochloric acid is further added to the mixture, and the mixture is stirred at room temperature for 6 hours. The obtained reaction solution is passed through a column filled with sodium hydroxide to obtain a tetrahydropyranyl ether in which the OH group of hydroxyethyl methacrylate is protected by a protecting group.

Provenance & Evidence