Hydrochloric Acid → 2-Hydroxyethyl Methacrylate

Participants

Reaction Steps

A screw mouth-type bottle containing 25 g (0.06 mol) of polyethylene glycol methacrylate (trade name: Blemmer PE 350; manufactured by Nippon Oil & Fats Co., Ltd.) and 5.9 g (0.07 mol) of dihydropyran (trade name: 3,4-Dihydro-2H-pyran; manufactured by Wako Pure Chemical Industries, Ltd.) is tightly closed by a ball cock and immersed in an ice bath. 0.02 g of concentrated hydrochloric acid is further added to the mixture, and the mixture is stirred at room temperature for 6 hours. The obtained reaction solution is passed through a column filled with sodium hydroxide to obtain tetrahydropyranyl ether in which the OH group of polyethylene glycol methacrylate is protected by a protecting group.

Provenance & Evidence