2-Naphthylamine → HCID 21938092, compound

HRID 1393556Notes

Reaction equation

HRID 1393556 reaction equation
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[NH2:22]>C(Cl)(Cl)Cl>[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[NH:22][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 70572-NaphthylamineHCID 5209483-Fluoro-4-nitrophenol

Product 1

HCID 21938092HCID 21938092, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
180 °C

Procedure

3 g of 3-fluoro-4-nitrophenol and 8.2 g of 2-naphthylamine were mixed and stirred for 8 hours at 180° C. The raw mixture was taken up in chloroform and washed with 2N aqueous hydrochloric acid. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was chromatographed on silica gel.

Workup

  1. washwashed with 2N aqueous hydrochloric acid
  2. customThe organic phase was dried on sodium sulfate
  3. concentrationconcentrated by evaporation in a vacuum
  4. customThe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-f2728b2ec0fe4b2cab5abe16bed67fc7
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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