Sodium Hydroxide → 5-Fluoro-2,4-dinitrophenol

HRID 1393561Notes

Reaction equation

HRID 1393561 reaction equation
[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4](F)[CH:3]=1.[OH-:15].[Na+]>O>[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([OH:15])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 675981,5-Difluoro-2,4-dinitrobenzene

Product 1

HCID 150838855-Fluoro-2,4-dinitrophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.41 g of 1,3-difluoro-4,6-dinitrobenzene was dissolved in 8 ml of 0.5 N aqueous sodium hydroxide solution and refluxed for 2 hours. After cooling, it was diluted with water and extracted three times with diethyl ether. The aqueous phase was made acidic by adding 1N hydrochloric acid and extracted with diethyl ether. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted three times with diethyl ether
  4. additionby adding 1N hydrochloric acid
  5. extractionextracted with diethyl ether
  6. customThe organic phase was dried on sodium sulfate
  7. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-e3e5da49018c417d908977728e0c8b4d
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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