Potassium Bicarbonate → HCID 10161570, compound

HRID 1393585Notes

Reaction equation

HRID 1393585 reaction equation
[CH3:1][O:2][C:3]1[C:24]([O:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:23][C:6]2[N:7]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:9][C:5]=2[CH:4]=1.[C:34](=O)(O)[O-].[K+]>CO.S(=O)(=O)(O)O.O>[CH3:34][O:32][C:31](=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][O:25][C:24]1[C:3]([O:2][CH3:1])=[CH:4][C:5]2[N:9]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:7]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[C:6]=2[CH:23]=1

Participants

6

Reactant 2

HCID 516893Potassium BicarbonateHCID 21938077HCID 21938077, compound

Product 1

HCID 10161570HCID 10161570, compound

Reagents, catalysts & solvents 3

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

40 mg of 6-[[5-methoxy-1-(4-methylphenyl)-2-phenyl-1H-benzimidazol-6-yl]oxy]hexanoic acid was dissolved in 2 ml of methanol, mixed with 1 drop of concentrated sulfuric acid, and the mixture was stirred for 2 hours. It was mixed with saturated potassium bicarbonate solution, diluted with water, extracted with ethyl acetate, the extracts were dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was crystallized from diisopropyl ether.

Workup

  1. extractionextracted with ethyl acetate
  2. customthe extracts were dried on sodium sulfate
  3. concentrationconcentrated by evaporation in a vacuum
  4. customThe residue was crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-519f2f49422b4aa9b53c3645d3f234a5
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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