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HRID 1393602作成日：2026年10月26日
Water → 5-[[(4-Chlorophenyl)sulfonyl][1,2-diphenyl-1H-benzimidazol-5-yl]amino]pentanoic acid methyl ester
https://huagongshe.com/reaction/1393602
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl 5-bromovalerate | HCID 79557 | — |
| 反応物 | 4-Chloro-N-(1,2-diphenyl-1H-benzimidazol-5-yl)benzenesulfonamide | HCID 21938028 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-[[(4-Chlorophenyl)sulfonyl][1,2-diphenyl-1H-benzimidazol-5-yl]amino]pentanoic acid methyl ester | HCID 67365751 | — |
反応手順
100 mg of 4-chloro-N-(1,2-diphenyl-1H-benzimidazol-5-yl)benzenesulfonamide was suspended in 0.5 ml of N,N-dimethylformamide, mixed with 8 mg of sodium hydride and stirred for 30 minutes at 20° C. 60 mg of 5-bromopentanoic acid methyl ester was added, it was allowed to stir for 15 hours, mixed with water, extracted three times with ethyl acetate, the extracts were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was chromatographed on silica gel.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07345075B2 |
|---|
| 出典データセット | uspto-grants-2008_03 |
|---|
| ORD ID | ord-ad638a7ea28541c9bd0677a15be42770 |
|---|
| 出典メモ | uspto-grants-2008_03 |
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