3-Cyanopyridine → Nicotinamide

HRID 1393621Notes

Reaction equation

HRID 1393621 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[OH2:9]>O=[Mn]=O>[C:1]([NH2:2])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1

Participants

4

Reactant 2

HCID 793-CyanopyridineHCID 962Water

Product 1

HCID 936NicotinamideYield 99%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Conditions

Temperature
105 °C

Procedure

0.096 mole of 3-cyanopyridine was dissolved in 5.556 mole of water and 0.0115 mole of MnO2, which prepared by above method, was added to this. The mixture was refluxed at 105° C. for 8 hrs. The reaction mixture was cooled and filtered. The filtrate was evaporated in dryness to get solid nicotinamide 0.095 mole. Yield of isonicotinamide was 98.9 mole %.

Workup

  1. additionwas added to this
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. customThe filtrate was evaporated in dryness

Sources & evidence

ORD record
ord-edc819ee7c8b4516b5c615c53fb9db8f
Source dataset
uspto-grants-2008_03
Patent number
US07345176B2

Reaction notes

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