HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | L-Prolinamide | HCID 111306 | — |
| Product | (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | HCID 11073883 | — |
Reaction Steps
In a similar procedure as employed in a patent (WO98/19998), L-proline amide (10.0 g) was reacted with chloroacetyl chloride (7.0 ml) and then subjected to dehydration reaction to give the title compound (7.7 g, yield (Y.:51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345180B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-3329fe81c9044ab7a9c4dace3e1eece1 |
| Source note | uspto-grants-2008_03 |