HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → (R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Prolinamide, D- | HCID 447554 | — |
| Product | (R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile | HCID 10920982 | 66% |
Reaction Steps
In a similar procedure as employed in the Intermediate Example 1, D-proline amide (3.2 g) was reacted with chloroacetyl chloride (2.5 ml) and then subjected to dehydration reaction to give the title compound (3.2 g, Y.:66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345180B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-97529f24edb74ab6b26e94f4daf428a6 |
| Source note | uspto-grants-2008_03 |