Sodium cyanoborohydride → HCID 57500592, compound

Participants

Reaction Steps

The (S)-N-{2-[2-(2-cyanopyrrolidin-1-yl)-2-oxoethylamino]-2-methyl-1-propyl}formamide (690 mg) obtained above was dissolved in MeOH (30 ml). Sodium cyanoborohydride (172 mg) was added there to and stirred for 6 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography (eluting solvent; dichloromethane:methanol 5:1→3:1) to give the title compound (455 mg, Y.:70%).

Provenance & Evidence