Sodium Hydroxide → 4-Methyl-4-nitropentanoic acid

Methyl 4-methyl-4-nitropentanoate (5.00 g) was dissolved in ethanol (25 ml), and 1 N sodium hydroxide solution was added thereto and stirred for 1 day. The mixture was concentrated under reduced pressure, then chloroform and water were added thereto, and the aqueous phase was washed with chloroform. 2 N Hydrochloric acid (20 ml) was added to the aqueous phase which was then extracted with chloroform, and the extract was dried over sodium sulfate anhydrous. The product was concentrated under reduced pressure to give 4-methyl-4-nitropentanoic acid (4.32 g, Y.:94%) as white crystals.

1. concentrationThe mixture was concentrated under reduced pressure
2. additionchloroform and water were added
3. washthe aqueous phase was washed with chloroform
4. addition2 N Hydrochloric acid (20 ml) was added to the aqueous phase which
5. extractionwas then extracted with chloroform
6. dry with materialthe extract was dried over sodium sulfate anhydrous
7. concentrationThe product was concentrated under reduced pressure

ORD record

ord-68c6c468b16a49cab4fc1ce52a299dc9

Source dataset

uspto-grants-2008_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07345180B2