反应详情

温度

70 °C

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid amide (475 mg) was dissolved in ethanol (5 ml), and 5 N sodium hydroxide solution (2 ml) was added thereto and stirred for 1 hour at 70° C. The reaction mixture was cooled to room temperature, water was added thereto, and the reaction mixture was washed with ethyl acetate. 2 N Hydrochloric acid was added to the aqueous phase until it became acidic, and precipitated crystals were collected by filtration and washed with water and n-hexane. The crystals were dried under reduced pressure to give the title compound (300 mg, Y.:63%) as white crystals.

1. temperatureThe reaction mixture was cooled to room temperature
2. washthe reaction mixture was washed with ethyl acetate
3. addition2 N Hydrochloric acid was added to the aqueous phase until it
4. customprecipitated crystals
5. filtrationwere collected by filtration
6. washwashed with water and n-hexane
7. customThe crystals were dried under reduced pressure