Ethyl Acetoacetate → Ethyl 2-acetyl-3-(dimethylamino)acrylate

Participants

Reaction Steps

Ethyl acetoacetate (35.4 g) was dissolved in acetonitrile (200 ml), and dimethylformamide dimethyl acetal (30.9 g) was added thereto, and the mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure to give ethyl 2-dimethylaminomethyleneacetoacetate (50.4 g, Y.:99%) as a red oil.

Provenance & Evidence