1,3-Diethyl 2-acetylpropanedioate → HCID 178469172, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-5-phenylpyrazole (1.56 mg) and diethyl acetomalonate (2.00 g) were dissolved in acetic acid (5.0 ml) and stirred for 3 hours at 120° C. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. Ethanol was added to the residue which were then cooled to 0° C. Precipitated crystals were collected by filtration and washed with cold ethanol. The crystals were dried under reduced pressure to give ethyl 7-hydroxy-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylate (2.73 g, Y.:92%) as white crystals.

Provenance & Evidence