1,4-Dioxane hydrochloride → HCID 178469450, compound

HRID 1393659Notes

Reaction equation

HRID 1393659 reaction equation
Cl.O1CCOCC1.C(OC([NH:18][C:19]1[N:23]([CH:24]=[C:25]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:26](OCC)=[O:27])[N:22]=[C:21]([CH3:36])[CH:20]=1)=O)C1C=CC=CC=1>>[OH:27][C:26]1[C:25]([C:31]([O:33][CH2:34][CH3:35])=[O:32])=[CH:24][N:23]2[N:22]=[C:21]([CH3:36])[CH:20]=[C:19]2[N:18]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57500597HCID 57500597, compound

Product 1

HCID 178469450HCID 178469450, compoundYield 73%

Procedure

4 N Hydrochloric acid/1,4-dioxane (2 ml) was added to the diethyl 2-(5-benzyloxycarbonylamino-3-methylpyrazol-1-ylmethylene)m alonate (100 mg) obtained above and stirred for 22 hours. Precipitated crystals were collected by filtration and dried under reduced pressure to give ethyl 5-hydroxy-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (40 mg, Y.:73%).

Workup

  1. customobtained above and
  2. customPrecipitated crystals
  3. filtrationwere collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-ba2353ef448d408882927f033df60c7b
Source dataset
uspto-grants-2008_03
Patent number
US07345180B2

Reaction notes

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