HCID 23091916, compound → 1-(2-Tert-butoxy-2-oxoethyl)-1H-indole-5-carboxylic acid

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Reaction Steps

The benzyl 1-t-butoxycarbonylmethyl-1H-indole-5-carboxylate (800 mg) obtained above was dissolved in ethanol, then 5% palladium on carbon (160 mg) was added thereto, and the mixture was stirred overnight at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (670 mg, Y.:quant.).

Provenance & Evidence