反应详情

温度

0 °C

Dichloromethane (2 ml) and triethylsilane (1 ml) were added to 1-methyl-1H-indole-5-carboxylic acid (100 mg). The mixture was cooled to 0° C., trifluoroacetic acid (1 ml) was added dropwise thereto, and the mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure, and precipitate was collected by filtration. The precipitate was washed with ether and dried under reduced pressure to give the title compound (66 mg, Y.:65%).

1. temperaturethe mixture was warmed to room temperature
2. concentrationThe reaction mixture was concentrated under reduced pressure, and precipitate
3. filtrationwas collected by filtration
4. washThe precipitate was washed with ether
5. customdried under reduced pressure