2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → 1-Acetyl-1H-indole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

1-Acetyl-2,3-dihydro-1H-indole-5-carboxylic acid (100 mg) was suspended in 1,4-dioxane (3 ml), and 2,3-dichloro-5,6-dicyano-p-benzoquinone (445 mg) was added thereto and stirred for 16 hours at 110° C. Solids were removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by preparative thin-layer chromatography (developing solvent; dichloromethane:methanol 20:1) to give the title compound (98 mg, Y.:99%).

Provenance & Evidence