HCID 23092005, compound → 1-Benzoyl-1H-indole-5-carboxylic acid

HRID 1393677Notes

Reaction equation

HRID 1393677 reaction equation
[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([O:20]CC3C=CC=CC=3)=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pd]>[C:1]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 23092005HCID 23092005, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 108907701-Benzoyl-1H-indole-5-carboxylic acidYield 67%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The benzyl 1-benzoyl-1H-indole-5-carboxylate (100 mg) obtained above was dissolved in ethanol, and 5% palladium on carbon (20 mg) was added thereto and stirred overnight at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (50 mg, Y.:66%) as white crystals.

Workup

  1. customInsoluble matter was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3deeb2a1cb454d628e50d6b372c2cd10
Source dataset
uspto-grants-2008_03
Patent number
US07345180B2

Reaction notes

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