Formic Acid → HCID 23091945, compound

HRID 1393680Notes

Reaction equation

HRID 1393680 reaction equation
[NH2:1][C:2]1[C:10]([SH:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[CH:14](O)=O>[Zn]>[CH3:13][O:12][C:3]1[C:2]2[N:1]=[CH:14][S:11][C:10]=2[CH:9]=[C:5]([C:6]([OH:8])=[O:7])[CH:4]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 23091979HCID 23091979, compound

Product 1

HCID 23091945HCID 23091945, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Conditions

Temperature
100 °C

Procedure

The 4-amino-5-mercapto-3-methoxybenzoic acid (670 mg) obtained above was heated at 50° C. in 90% formic acid (6.0 ml), and zinc powder (15 mg) was added thereto. The mixture was stirred for 2 hours at 100° C. and then cooled to room temperature, and precipitated crystals were collected by filtration, washed with water and dried under reduced pressure to give the title compound (470 mg, Y.:67%) as white crystals.

Workup

  1. temperaturecooled to room temperature
  2. customprecipitated crystals
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-f6efd9b4fe2c4a5a81c6e0a0d5d91866
Source dataset
uspto-grants-2008_03
Patent number
US07345180B2

Reaction notes

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