Acetic Anhydride → 4-Methoxy-2-methyl-6-benzothiazolecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

4-Amino-3-mercapto-5-methoxybenzoic acid (500 mg) was dissolved in tetrahydrofuran (15 ml) and cooled at −78° C. Acetic anhydride (0.26 ml) was added thereto, and the mixture was warmed over 30 minutes to room temperature and stirred for 3 hours. The reaction mixture was concentrated under reduced pressure to give the title compound (550 mg, Y.:99%) as white crystals.

Provenance & Evidence