HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 57500600, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | t-butyl (S)-[2-(cyanopyrrolidin-1-yl)-2-oxoethyl]-[2-(1,3-dihydrois oindol-2-yl)-2-oxoethyl]carbamate | HCID 86608409 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57500600 | HCID 57500600 | 113.2% |
Reaction Steps
The t-butyl (S)-[2-(cyanopyrrolidin-1-yl)-2-oxoethyl]-[2-(1,3-dihydrois oindol-2-yl)-2-oxoethyl]carbamate (280 mg) obtained above was dissolved in 1,4-dioxane (1.0 ml), and 4 N Hydrochloric acid/1,4-dioxane (1.0 ml) was added thereto and stirred for 30 minutes with ice cooling. Ether was added thereto, and precipitated crystals were collected by filtration and dried under reduced pressure to give a hydrochloride (240 mg, Y.: quant.) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345180B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-7822c17ba6fc4478a4eab3979c6aa6ad |
| Source note | uspto-grants-2008_03 |