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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 139382Generated: October 27, 2026

Water → 4-[1-Carboxy-2-(4-fluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/139382

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantDiethyl EtherHCID 3283—
ReactantDiisopropylamineHCID 7912—
ReactantTetrahydrofuranHCID 8028—
Reactant3-(4-Fluorophenyl)propionic acidHCID 136302—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
ReactantButyllithiumHCID 178418339—
Product4-[1-Carboxy-2-(4-fluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl esterHCID 57458011—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-e936dc11952e4e6181cef1d2beabbd7d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)