HCID 10380701, compound → HCID 66936661, compound

Participants

Reaction Steps

A mixture of biphenyl-2-ylcarbamic acid 4-methylpiperidin-4-yl ester (2.73 g, 8.79 mmol) and N-(4-[1,3]dioxolan-2-yl-phenyl)acrylamide (2.05 g, 8.80 mmol) were heated in 100 mL of 1:1 methanol/dichloromethane at 50° C. under nitrogen for 1 h. The solution was then diluted with ethyl acetate and the organic layer was washed with water, brine, dried (MgSO4) and concentrated under reduced pressure to give the title compound. MS m/z calcd for C31H35N3O5 (M+H)+ 530.6; found 530.4.

Provenance & Evidence