Water → HCID 458932, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of zinc powder (2 g) and ammonium chloride (0.2 g) in 22 ml of a water/ethanol mixture (1/1) was refluxed in a boiling-water bath. The derivative N-{2-[(4nitrophenyl)amino]ethyl}benzenesulfonamide (2) (3 g, 9 mmol) was added in portions and heating was continued until the reaction medium decolorized. The mixture was filtered while hot and the zinc was rinsed with ethanol/water solution (50/50). The filtrate crystallized rapidly. After cooling to 0° C., the solid was filtered off and then washed with water. After drying, 2.27 g of crude product with a melting point of 144° C. were obtained. 0.77 g of this crude product was recrystallized from 20 mL of water/ethanol (1/1), and the crystals obtained were dried over P2O5 and microanalysed.

Provenance & Evidence