Water → HCID 69203940, compound

Participants

Reaction Steps

A mixture of zinc powder (3.8 g), ammonium chloride (0.22 g), water (0.75 mL), and 96% ethanol (10 mL) was refluxed in a boiling water bath. The derivative 2-[(4-nitrophenyl)amino]-N-(tetrahydrofuran-2-ylmethyl)ethanesulfonamide (10) (2.52 g, 7.6 mmol) was added in portions and heating was continued until the reaction medium decolorized. The resulting mixture was filtered while boiling and the filtrate was recovered onto 12 mL of ethanol and 1.5 mL of concentrated hydrochloric acid. Acetone was added to precipitate the hydrochloride formed (1.8 g). The product was filtered off and recrystallized from 15 mL of ethanol to give 0.8 g of dihydrochlorided product with the following elemental analyses:

Provenance & Evidence