反应详情

Ethyl 2-{benzyl[(4-methoxyphenyl)sulfonyl]amino}acetate (11.62 g, 31.97 mmol) was dissolved in ethanol (100 ml), and 1N sodium hydroxide (100 ml) was added thereto. After being reacted for 16 hours at room temperature, the solvent was evaporated out. 3N hydrochloric acid (150 ml) was added to the residue and the water phase was extracted with ethyl acetate (200 ml×2). The organic layer was washed with saturated brine, and then dried over sodium sulfate. The solvent was evaporated out and the residue was purified by silica gel column chromatography (chloroform:methanol=10:1), to give 2-{benzyl[(4-methoxyphenyl)sulfonyl]amino}acetic acid (10.57 g, 99%).

1. customAfter being reacted for 16 hours at room temperature
2. customthe solvent was evaporated out
3. addition3N hydrochloric acid (150 ml) was added to the residue
4. extractionthe water phase was extracted with ethyl acetate (200 ml×2)
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over sodium sulfate
7. customThe solvent was evaporated out
8. customthe residue was purified by silica gel column chromatography (chloroform:methanol=10:1)