Homogentisic Acid → Methyl 2-(2,5-dihydroxyphenyl)acetate

HRID 1393875Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[CH3:18]O>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH2:9][C:10]([O:12][CH3:18])=[O:11]

Participants

Reactant 3

HCID 780Homogentisic Acid

HCID 887Methanol

HCID 1118Sulfuric Acid

Product 1

HCID 13790504Methyl 2-(2,5-dihydroxyphenyl)acetate

Procedure

2,5-Dihydroxyphenylacetic acid is refluxed in methanol in the presence of sulfuric acid, to give methyl 2-(2,5-dihydroxyphenyl)acetate.

Sources & evidence

ORD record: ord-a182c448478147f59ed2681205ad2b5c
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07348017B2

Reaction notes

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