Methanol → Methyl 4-bromo-alpha-hydroxybenzeneacetate

HRID 1393882Notes

Reaction equation

[Br:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([OH:9])=[O:8])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:18]O>>[Br:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]([OH:10])[C:7]([O:9][CH3:18])=[O:8])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 887Methanol

HCID 1118Sulfuric Acid

HCID 97930p-Bromomandelic acid

Product 1

HCID 14571696Methyl 4-bromo-alpha-hydroxybenzeneacetate

Procedure

4-Bromomandelic acid, with sulfuric acid added thereto, is reacted in methanol, to give methyl 2-(4-bromophenyl)-2-hydroxyacetate.

Sources & evidence

ORD record: ord-505e6ada21d943ee9f2e446319fd5970
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07348017B2

Reaction notes

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