Diethyl Oxalate → HCID 136007385, compound

Participants

Reaction Steps

A mixture of 1.5 g (8.7 mmol) 2-chloro-4-methyl-5-nitropyridine (commercially available) in 5.88 mL (43.5 mmol) diethyl oxalate was treated with 2.34 ml (15.6 mmol) 1,8-diazabicylo[5.4.0]undec-7-ene and stirred for 4 h at room temperature. After evaporation of all volatiles the residue was acidified with 1N KHSO4 aq. and extracted with DCM. The combined organic layers were dried with MgSO4 and concentrated under reduced pressure to afford 3.16 g of the title compounds which was used without further purification in the next step.

Provenance & Evidence