1-Cyclopentylpiperazine → HCID 136392270, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3.16 g (Z)-3-(2-chloro-5-nitro-pyridin-4-yl)-2-hydroxy-acrylic acid ethyl ester in 40 mL DMF was treated with 2.96 g (192 mmol) 1-cyclopentyl-piperazine and heated to 110° C. for 1.5 h. The mixture was diluted with 1N NaHCO3 aq. and extracted with DCM. The combined organic layers were dried with MgSO4 and evaporated to dryness to yield the title compound which was used without further purification.

Provenance & Evidence