Hydroxyamine hydrochloride → HCID 86612934, compound

Participants

Reaction Steps

A solution of 29 mg of 4-methyl-6-{2-oxo-3-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propylamino}-benzo[d][1,2]oxazin-1-one in EtOH (8 ml) was treated with 1 ml of 50% NH2OH HCl solution in H2O and NaOAc (15 mg). The solution was heated under reflux for 2 h and evaporated. The residue was purified by column chromatography on silica gel (10%-40% EtOAc-hexane) to yield 2 mg of product.

Provenance & Evidence