HCID 86599748, compound → HCID 86599749, compound

HRID 1393916Notes

Reaction equation

HRID 1393916 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:24][CH2:25][CH2:26][CH3:27])([NH:20][CH2:21][CH2:22][CH3:23])=[O:19])[C:13]1=[O:28])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:24][CH2:25][CH2:26][CH3:27])([NH:20][CH2:21][CH2:22][CH3:23])=[O:19])[C:13]1=[O:28]

Participants

4

Reactant 1

HCID 86599748HCID 86599748, compound

Product 1

HCID 86599749HCID 86599749, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (50 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-bis(n-propylamino)phosphinyl-2-piperidone (500.0 mg, 1.2182 mmol) in methanol (5 mL), and the resulting mixture was stirred at room temperature for 3 hours under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-cfa1293142554cf7ada5617aaa23681d
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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