HCID 86599750, compound → HCID 86599751, compound

HRID 1393918Notes

Reaction equation

HRID 1393918 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:19])[C:13]1=[O:34])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:19])[C:13]1=[O:34]

Participants

4

Reactant 1

HCID 86599750HCID 86599750, compound

Product 1

HCID 86599751HCID 86599751, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (31 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-bis(n-hexylamino)phosphinyl-2-piperidone (310.9 mg, 0.6286 mmol) in methanol (3 mL), and the resulting mixture was stirred at room temperature for 1 hour under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-adbc8d6fb1e6456a8ef7196b33451779
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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