HCID 86599752, compound → HCID 86599753, compound

HRID 1393920Notes

Reaction equation

HRID 1393920 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:19])[C:13]1=[O:34])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:19])[C:13]1=[O:34]

Participants

4

Reactant 1

HCID 86599752HCID 86599752, compound

Product 1

HCID 86599753HCID 86599753, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (20 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-bis(phenylamino)phosphinyl-2-piperidone (200.2 mg, 0.4184 mmol) in methanol (4 mL), and the resulting mixture was stirred overnight at room temperature under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-c0977cd5108f4d44a1dc5ac064fcbcc9
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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