HCID 86599755, compound → HCID 86599754, compound

HRID 1393921Notes

Reaction equation

HRID 1393921 reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=2)([NH:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)=[O:19])[C:13]1=[O:38])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][CH2:15][N:14]([P:18]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)([NH:29][C:30]2[CH:31]=[CH:32][C:33]([O:36][CH3:37])=[CH:34][CH:35]=2)=[O:19])[C:13]1=[O:38]

Participants

4

Reactant 1

HCID 86599755HCID 86599755, compound

Product 1

HCID 86599754HCID 86599754, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium black (30 mg) was added to a solution of (3S)-3-benzyloxycarbonylamino-1-bis(4-methoxyphenylamino)phosphinyl-2-piperidone (150.2 mg, 0.2789 mmol) in methanol (5 mL), and the resulting mixture was stirred overnight at room temperature under a hydrogen atmosphere.

Sources & evidence

ORD record
ord-45ba85aa574942a0a1682ac8c55377a0
Source dataset
uspto-grants-2008_03
Patent number
US07348318B2

Reaction notes

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