Methyl iodide → HCID 178503336, Verbindung

HRID 1393951Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393951
[CH3:1][I:2].[NH:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][NH:5][C:4]1=[S:13]>C(O)C>[IH:2].[CH3:1][S:13][C:4]1[NH:5][CH2:6][C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 36448543,4-dihydro-1H-quinazoline-2-thione

Produkt 1

HCID 178503336HCID 178503336, VerbindungAusbeute 68,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl iodide (11.5 ml, 184 mmol) was added to a solution of 3,4-dihydro-1H-quinazoline-2-thione (7.55 g, 46 mmol) in ethanol (150 ml), and the mixture was heated to reflux (3.5 h). The majority of the solvent was then evaporated under reduced pressure, and the precipitate was collected by filtration and washed with a small amount of cold ethanol. The thus obtained title compound (9.60 g, 68%) was used in the next step without further purification.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux (3.5 h)
  3. customThe majority of the solvent was then evaporated under reduced pressure
  4. filtrationthe precipitate was collected by filtration
  5. washwashed with a small amount of cold ethanol

Quellen und Nachweise

ORD-Eintrag
ord-5fa6055ef29a4b6e9b8850763e110b42
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07348332B2

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