(+-)-1-Aminoindan → HCID 178420156, compound

HRID 1393956Notes

Reaction equation

HRID 1393956 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.I.CS[C:14]1[NH:23][CH:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=1>>[CH:2]1([NH:1][C:14]2[NH:23][CH:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 123445(+-)-1-AminoindanHCID 178503332HCID 178503332, compound2×

Product 1

HCID 178420156HCID 178420156, compound

Procedure

The title compound (MS: m/e=340.3 [M+H+]) was prepared in analogy to example 1 (b) from (+/−)-1-aminoindan and 2-methylsulfanyl-4-phenyl-3,4-dihydro-quinazoline hydroiodide. 2-Methylsulfanyl-4-phenyl-3,4-dihydro-quinazoline hydroiodide can be prepared by the method of Kosasayama, A.; Higashi, K.; Ishikawa, F. Chem. Pharm. Bull. 1979, 27(4), 880-892.

Sources & evidence

ORD record
ord-a11d5ae0fa44453c85ef35cf35d8d485
Source dataset
uspto-grants-2008_03
Patent number
US07348332B2

Reaction notes

Loading…