(+-)-1-Aminoindan → HCID 178477844, compound

HRID 1393957Notes

Reaction equation

HRID 1393957 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.[Cl:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17](SC)[NH:16][CH:15]2[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([NH:1][CH:2]1[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3]1)[NH:16][CH:15]2[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 123445(+-)-1-AminoindanHCID 178503340HCID 178503340, compound2×

Product 1

HCID 178477844HCID 178477844, compound

Procedure

The title compound (MS: m/e=374.1 [M+H+]) was prepared in analogy to example 1 (b) from (+/−)-1-aminoindan and 6-chloro-2-methylsulfanyl-4-phenyl-3,4-dihydro-quinazoline. 6-Chloro-2-methylsulfanyl-4-phenyl-3,4-dihydro-quinazoline can be prepared by the method of Richter, P.; Oertel, F. Pharmazie 1990, 45(10), 721-724.

Sources & evidence

ORD record
ord-2b90598e75b44d9791a91c763003655c
Source dataset
uspto-grants-2008_03
Patent number
US07348332B2

Reaction notes

Loading…