Dimethylformamide → HCID 10137846, compound

Participants

Reaction Steps

To a solution of 1-[2-ethyl-6-oxo-4-phenyl-1,6-dihydro-1-pyrimidinyl]-2-(aminophenoxy)ethane (1.9 g, 5.67 mmol) (Ref. U.S. Pat. No. 6,310,069) in dry DMF (20 mL) was added K2CO3 and stirred at RT for 30 min. To this ethyl-2-bromopropanoate (1.54 g, 8.51 mmol), was added and the mixture was stirred at 50° C. for 14 h. The reaction mixture was filtered, washed with EtOAc and the combined filtrates were washed with water and extracted with EtOAc. The organic layer was dried over Na2SO4, evaporated the solvent and the crude compound was purified by column chromatography by eluting with 25% EtOAc:pet. ether to give the title compound as a brownish low melting solid (mp: 40° C., 1.867 g, 76%).

Provenance & Evidence