HCID 86585522, compound → HCID 178517604, compound

HRID 1393985Notes

Reaction equation

HRID 1393985 reaction equation
[OH:1][CH:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:11]=3)[C:6]=2[CH:5]=[CH:4][NH:3]1>[Pd]>[OH:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]([F:18])([F:16])[F:17])[CH:11]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 86585522HCID 86585522, compound

Product 1

HCID 178517604HCID 178517604, compoundYield 16.8%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
50 °C

Procedure

A portion of dihydro 1-hydroxy-7-trifluoromethyl-β-carboline (6 mg) in xylenes (1 ml) was treated with Pd/C (10%, 7 mg) and the mixture heated at 50° C. for one week. The reaction was concentrated after filtering it through celite, and the residue was chromatographed (1:1 hexane-ethyl acetate) on silica gel to give 1 mg of 1-hydroxy-7-trifluoromethyl-β-carboline.

Workup

  1. concentrationThe reaction was concentrated
  2. filtrationafter filtering it through celite
  3. customthe residue was chromatographed (1:1 hexane-ethyl acetate) on silica gel

Sources & evidence

ORD record
ord-b02d3b67d3ad4f40903c1369f2c063c5
Source dataset
uspto-grants-2008_03
Patent number
US07348336B2

Reaction notes

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