反应详情

100 mg (0.2 mmol) of (2S)-2-benzyloxycarbonylamino-3-(4-(2-(1,4,5,6-tetra-hydropyrimidin-2-ylcarbamoyl)ethyl)benzoylamino)propionic acid (Example 3e) were dissolved in 15 ml of dioxane, treated with 0.012 ml of glacial acetic acid and hydrogenated at RT and 1 bar H2 over Pd/C (5%). After 2 h, 15 ml of methanol were added and the mixture was hydrogenated at RT and 1 bar H2 for a further 5 h. It was filtered and the solvent was evaporated in vacuo. Yield: 67.4 mg (93%). MS: ES+, m/e=362.2 (M+H+, 30%); 173.0 (100).

1. customwas hydrogenated at RT
2. wait1 bar H2 for a further 5 h
3. filtrationIt was filtered
4. customthe solvent was evaporated in vacuo