HRID1394015

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)[C@H](Cc1ccc(OCCCC(=O)NC2=NCCN2)cc1)NC(=O)OCC12CC3CC(CC(C3)C1)C2

HCID67633290

未命名化合物

PRODUCTS

生成物

结构：O=C(CCCOc1ccc(C[C@H](NC(=O)OCC23CC4CC(CC(C4)C2)C3)C(=O)O)cc1)NC1=NCCN1

HCID57027538

未命名化合物

收率 99.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22392675

未命名化合物

PROCEDURE

实验过程

188 mg (0.32 mmol) of (5.1) were dissolved in 10 ml of trifluoroacetic acid/H2O (95:5). After 30 min, the solvent was removed in vacuo and the residue was digested with diisopropyl ether. After freeze-drying, 168 mg of an amorphous powder of (5.2) were obtained.

WORKUP

后处理

customthe solvent was removed in vacuo
customAfter freeze-drying

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9a56a6af60fc42aeb8b078ad01b0a541
来源数据集: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07348333B2
来源说明: uspto-grants-2008_03

反应 SMILES

[C:1]12([CH2:11][O:12][C:13]([NH:15][C@@H:16]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][CH2:34][C:35](=[O:42])[NH:36][C:37]4[NH:38][CH2:39][CH2:40][N:41]=4)=[CH:27][CH:26]=3)[C:17]([O:19]C(C)(C)C)=[O:18])=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>FC(F)(F)C(O)=O.O>[C:1]12([CH2:11][O:12][C:13]([NH:15][C@@H:16]([CH2:24][C:25]3[CH:26]=[CH:27][C:28]([O:31][CH2:32][CH2:33][CH2:34][C:35](=[O:42])[NH:36][C:37]4[NH:41][CH2:40][CH2:39][N:38]=4)=[CH:29][CH:30]=3)[C:17]([OH:19])=[O:18])=[O:14])[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2