反应详情

To a solution of 5-pyridin-2-yl-thiophene-2-sulfonyl chloride (0.213 g) [in CH2Cl2 (10 ml)] was added a solution of the product of Example 4, Step (b) (0.210 g) [in CH2Cl2 (5 ml) and pyridine (0.066 ml)]. The reaction was left to stir for 12 hrs. The reaction mixture was washed with saturated aqueous NaCl solution and the organics separated and dried and then filtered. The solvents were evaporated and the product purified by using reverse phase HPLC {with a gradient eluent system [25% MeCN/NH4OAcaq (0.1%) to 95% MeCN//NH4OAcaq (0.1%)]} give the title compound as a solid (0.03 g).

1. waitThe reaction was left
2. washThe reaction mixture was washed with saturated aqueous NaCl solution
3. customthe organics separated
4. customdried
5. filtrationfiltered
6. customThe solvents were evaporated
7. customthe product purified