Methanol → Methyl 1-benzyl-5-oxo-2-pyrrolidinecarboxylate

HRID 1394070노트

반응식

HRID 1394070 반응식
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][CH:9]1[C:14]([OH:16])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:22]O>>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH2:10][CH:9]1[C:14]([O:16][CH3:22])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3228021-Benzyl-5-oxopyrrolidine-2-carboxylic acid

생성물 1

HCID 11096495Methyl 1-benzyl-5-oxo-2-pyrrolidinecarboxylate

실험 절차

1-Benzyl-5-oxo-2-pyrrolidinecarboxylic acid (9.69 g, 44.2 mmol) in methanol (75 mL) was treated with sulfuric acid (0.5 mL) and refluxed for 2.5 hours. The mixture was allowed to cool to room temperature and concentrated under reduced pressure. The residue was dissolved in ethyl acetate and washed with saturated sodium bicarbonate solution. The ethyl acetate phase was concentrated under reduced pressure to provide the title compound which was used in the next step without further purification.

후처리

  1. temperaturerefluxed for 2.5 hours
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washwashed with saturated sodium bicarbonate solution
  5. concentrationThe ethyl acetate phase was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c56630be8bed4db9909244727946ba42
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07348343B2

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