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HRID1394088

反应详情

EQUATION

反应方程式

HRID 1394088 的结构方程式

REACTANTS

反应物

4
结构：CO
HCID887

Methanol

CH4O

结构：CCCCCC
HCID8058

n-Hexane

C6H14

结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：N#CC1(O)CCN(Cc2ccccc2)CC1
HCID80189

1-Benzyl-4-hydroxypiperidine-4-carbonitrile

C13H16N2O

PRODUCTS

生成物

1
结构：COC(=O)C1(O)CCN(Cc2ccccc2)CC1
HCID12343427

Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

C14H19NO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

PROCEDURE

实验过程

1-Benzyl-4-hydroxy-4-piperidinecarbonitrile (30.0 g, 118 mmol) in methanol (590 mL) and concentrated HCl (590 mL) was heated at reflux for 18 hours. The product was obtained following chromatography (SiO2, ethyl acetate:hexane, 1:4). MS (EI, M+H)+ 250.

WORKUP

后处理

  1. temperatureat reflux for 18 hours
  2. customThe product was obtained