Methanol → Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate
Reaktionsgleichung
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([OH:16])([C:14]#N)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17](OCC)(=[O:19])C.CCCCCC.C[OH:30]>Cl>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([OH:16])([C:14]([O:19][CH3:17])=[O:30])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1-Benzyl-4-hydroxy-4-piperidinecarbonitrile (30.0 g, 118 mmol) in methanol (590 mL) and concentrated HCl (590 mL) was heated at reflux for 18 hours. The product was obtained following chromatography (SiO2, ethyl acetate:hexane, 1:4). MS (EI, M+H)+ 250.
Aufarbeitung
- temperatureat reflux for 18 hours
- customThe product was obtained
Quellen und Nachweise
- ORD-Eintrag
- ord-d7bb89b3c1984952ae561f7720d8e54c
- Quelldatensatz
- uspto-grants-2008_03
- Patentnummer
- US07348343B2
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