Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 68679084, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Example 1A (5.77 g, 0.0192 mol) in anhydrous dichloromethane (30 mL) was added methyl (triphenylphosphoranylidene)-acetate (8.22 g, 0.0246 mol) and the resulting solution heated to 40° C. for two days. The mixture was cooled, concentrated and purified by column chromatography (ethyl acetate/hexane, 4/6) to provide the titled compound (3.42 g). MS (ESI APCI) m/e 355 (M−H)+; 1H NMR (400 MHz, DMSO-d6): δ ppm 5.87 (m, 1H), 4.41-4.78 (m, 4H), 4.31 (d, 1H), 3.74-3.78 (m, 2H), 3.17 (t, 2H), 3.04 (t, 1H), 2.74-2.80 (d, 1H), 1.40 (s, 9H).

Provenance & Evidence