Hydrochloric Acid → HCID 178523393, compound

Participants

Reaction Steps

To a solution of Example 30B (292.8 mg, 0.6 mmol) dissolved in methanol (10 mL) was added a solution of 4N HCl in dioxane (1.5 mL, 4 M, 6 mmol) via syringe at room temperature. The mixture was allowed to stir for 12 hours at room temperature, concentrated under reduced pressure to provide the titled compound. MS (ESI) m/e 388 (M+H)+, 386 (M−H)−; 1H NMR (500 MHz, CD3OD) δ ppm 1.97 (m, 1H) 2.86 (m, 2H) 3.16 (m, 2H) 3.39 (m, 1H) 3.61 (s, 2H) 3.69 (m, 1H) 3.76 (s, 2H) 3.97 (m, 1H) 4.53 (m, 2H) 7.69 (m, 1H) 8.07 (m, 1H) 8.20 (m, 1H) 8.57 (s, 1H).

Provenance & Evidence